It is important that this medication be given exactly as recommended by your doctor. If you miss an appointment to receive natalizumab, contact your doctor as soon as possible to reschedule your appointment.
The safety and effectiveness of this drug when used for longer than 2 years has not been established. Store unopened vials of this medication in the refrigerator.
Protect from light, and keep out of the reach of children. Do not shake the container or allow it to freeze. Do not dispose of medications in wastewater e. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects.
A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome.
Your pharmacist may be able to advise you on managing side effects. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Stop taking the medication and seek immediate medical attention if any of the following occur:. Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. Measure content performance. Develop and improve products. List of Partners vendors. Tysabri natalizumab is a prescription immunomodulator drug used to treat multiple sclerosis MS.
With this disease, the immune system damages the myelin that coats your nerves, not allowing them to work properly. Tysabri prevents certain immune cells in your bloodstream from crossing the blood-brain barrier , which helps protect the myelin in your brain and spinal cord from being damaged.
Tysabri is used as a disease-modifying therapy, which means it's intended to slow the progression of the disease rather than to manage symptoms. It's approved by the U. While Tysabri is shown to be effective, it isn't considered a first-line treatment because, in rare cases, it can cause a potentially fatal brain infection see below.
Numerous studies have demonstrated the drug's effectiveness in RRMS, with the benefits being:. A study of Tysabri in patients with SPMS did not show any benefit in slowing disability progression measured by a combination of tests; however, there was some suggestion of benefit in slowing the loss of function of the upper extremities. Further studies are needed to confirm this finding.
Tysabri is a monotherapy, meaning it's not combined with other MS medications. The drug is administered as an infusion given through your vein once every 28 days. You have to go to an infusion center, or sometimes a healthcare provider's office, to have it done. Common side effects of Tysabri include:. If any of these side effects become especially bothersome or don't go away, let your healthcare provider know.
More serious side effects are possible. If you experience or suspect any of the following, you should contact your healthcare provider immediately:. The most serious but rarest risk of taking Tysabri is progressive multifocal leukoencephalopathy PML , which is a potentially fatal brain infection caused by the John Cunningham JC virus.
You also need to be aware that there can be consequences when you start and then stop Tysabri. The Walkie Talkies team conquer km of the Jurassic Coast for the MS Trust The challenges of choosing a DMD as a new mother The group of MS nurses covering 1, miles to say thank you for their education Trial reports myelin repair success Under-the-skin injection of Tysabri gets licence in UK and Ireland Update on coronavirus COVID and multiple sclerosis Using creativity to cope with long-term conditions like MS Walking difficulties: getting your walking back on track after lockdown We are planning to make it an annual event!
What does the future look like for community MS support? What led Trishna to become a health and disability advocate? When will people with MS get a covid vaccine? Who gets MS and why? Would having children be impossibly hard for me, my partner, and the children themselves?
Research Brain training: a cognitive rehabilitation programme evaluated Can standing frames improve mobility in progressive MS? Do medicines reduce fatigue in MS? Effect of vitamin D supplements on MS activity Exercise is good for your brain How do families affected by MS manage health information? How does multiple sclerosis affect dating and romantic relationships? How long does it take for an MS drug to be fully effective? Learning a second language improves brain structures in MS MRI reveals smouldering MS lesions MS onset in childhood: do disease modifying drugs delay long term disability?
Stem cell transplants in the news Temelimab: early clinical trial suggests potential for remyelination Testing iStep-MS, a new programme to encourage physical activity Treatments for foot drop compared Tysabri risk of PML with extended interval dosing. Other names: natalizumab. Common side effects include dizziness, nausea, urticaria a skin rash and shivering. What is Tysabri used for in MS? Who can take Tysabri? Contraindications It is important that you tell your MS team if you have any health problems or are taking other medicines.
Conception and pregnancy Pregnancy is not recommended during treatment with Tysabri. How do I take Tysabri? What side effects could I get with Tysabri? Common side effects affecting more than 1 person in urinary tract infections inflammation of the nose shivering itchy rash urticaria headache dizziness nausea, vomiting joint pain fever Less common side effects affecting less than 1 person in severe allergic reaction during infusion rash, swelling of face, lips or tongue,difficulty breathing discomfort during the infusion including feeling sick, headache, dizziness progressive multifocal leukoencephalopathy PML serious infections liver problems A full list of side effects is included in the manufacturer's Patient Information Leaflet.
Assessment before treatment Blood tests will be performed before starting treatment to determine whether you have been previously infected by the JC virus. Assessment during treatment Prior to each infusion, blood pressure, temperature and pulse rate will be taken. Toothaches can be a symptom of an infection. So Tysabri increases your risk of infections, including those of the teeth and mouth. Toothache pain is usually a sign of a cavity or gum infection.
If not treated promptly, cavities can lead to an abscessed tooth a tooth that has a pocket of pus. Infection from the abscessed tooth can spread into your bloodstream and become serious. To help prevent teeth-related side effects, be sure to use good dental hygiene during Tysabri treatment. This includes regular brushing , flossing , and visiting your dentist and dental hygienist for routine checkups and cleanings.
If you notice tooth pain or sensitivity during Tysabri treatment, see your dentist right away. During studies of the drug, some people had menstrual cycle changes with Tysabri treatment.
Menstrual cycle changes with Tysabri may include painful periods , missed periods, or irregular cycles. In studies , some people who took Tysabri had weight gain or weight loss. Note that weight changes were only seen in studies of the drug as a treatment for multiple sclerosis MS. Symptoms of MS, such as fatigue low energy and weakness, can sometimes make it tough to exercise regularly.
Medications used to treat MS symptoms can also play a role in weight changes. If you notice weight changes that concern you during Tysabri treatment, talk with your doctor. They may be able to help you identify and manage factors that could be affecting your weight. They may also suggest diet or exercise changes to maintain a moderate weight with your condition. Infusion -related reactions may happen with Tysabri treatment. Infusion-related reactions are side effects that occur within 2 hours after the start of a Tysabri infusion.
In studies , infusion-related side effects were more common in people treated with Tysabri than in people who received a placebo. Severe allergic reactions seem to be more common in people who take breaks from Tysabri treatment and then start receiving it again.
Your risk of infusion-related reactions may be higher with your first infusion after taking a break from Tysabri treatment. Because of the risk of infusion-related reactions, only a healthcare professional can give you a Tysabri treatment. Infusion-related symptoms can include:.
For most people, infusion-related side effects such as headache or dizziness are mild. They should go away on their own. If you notice any of the above symptoms during or after receiving a Tysabri infusion, alert your healthcare professional right away. Tysabri has a boxed warning for a rare brain infection called PML. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Infection with PML usually leads to severe disability, such as being unable to walk, or even death.
The chance of getting PML with Tysabri is rare. But people with all three of the following factors have the highest risk of developing PML:. Your doctor can tell you more about this program. During treatment with Tysabri and for 6 months after your last infusion, your doctor will monitor you for symptoms of PML. If you develop any symptoms, tell your doctor right away. If you have questions about your risk of PML with Tysabri, talk with your doctor.
Tysabri may increase the risk of liver damage. Although not seen during studies of Tysabri, this side effect has since been reported in some people receiving the drug.
Another sign of liver damage is increased liver enzymes, as seen in blood test results.
0コメント