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If I am unsure about having an abortion, what are the other options in front of me? What are the two main types of abortion? The number of ongoing pregnancies documented with misoprostol-only warranted an early end of the trial after unblinding of the study at interim analysis. Policymakers should advocate for greater access to mifepristone.
Future research should prioritize misoprostol-only regimens with shorter dosing intervals. Abstract Background: Nonsurgical abortion methods have the potential to improve access to high-quality abortion care. Mifepristone has several other effects on the uterus and cervix during pregnancy. First, mifepristone alters the endometrium directly by effecting the capillary endothelial cells of the decidua, separation of trophoblast from the decidual, causing bleeding and a decrease in the human chorionic gonadotropin secretion into the maternal system.
The decidual reaction also increases prostaglandin release. Beside it, Mifepristone softens the cervix to allow expulsion. Mifepristone is not an effective treatment for extrauterine pregnancy. After oral intake peak plasma concentration is achieved within hours, Half life of Mifepristone is hours.
Misoprostol is a synthetic prostaglandin, which induces uterine contractions and expulsion of uterine contents and is used in combination with mifepristone for medical abortion. Acceptance of regimes of medical abortion with intervals of 24 and 48 hours between Mifepristone and Misoprostol intake. Informed written consent was taken from all participants who attended OPD with early pregnancy and wanted abortion by medical method.
USG was done for all women to confirm presence of intrauterine pregnancy and the gestational age. Blood group of all patients was done.
All medicines were taken orally at home. It was a randomised controlled trial of women- 75 in each group. One group took Mifepristone and Misoprostol tablets at 24 hours interval and second group took then at 48 hours interval. Mifepristone mg orally followed by misoprostol microgram orally after 24hours in group A and after 48 hours in group B. They were advised to come for emergency care in case of excessive bleeding per vaginum or unbearable pain in abdomen.
Ultrasonography was advised after 15 days to rule out retained product of conception. Patients were interviewed for amount of blood loss and intake of medicine for pain. Failure was considered in those where pregnancy was found intact in uterine cavity on USG.
Data was statistically described in terms of frequencies number of cases and percentages.
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